Abstract Background Premature ovarian insufficiency (POI) is an ovarian dysfunction disorder that significantly impacts female fertility. Ovarian granulosa cells (GCs) are crucial somatic components supporting oocyte development that rely on glycolysis for energy production. which is essential for follicular growth. Hypoxia-induced exosomal circRNAs regulate glycolysis. https://www.parisnaturalfoodes.shop/product-category/cold-flu-rescue/