A structure-guided modelling approach using COX-2 as a template was used to investigate the effect of replacing the chloro atom located at the chlorophenyl ring of amide-linked bipyrazole moieties. aiming at attaining better anti-inflammatory effect with a good safety profile. Bromo. fluoro. https://ashleyshomestores.shop/product-category/king-metal-hdbd-ftbd-rails/